Debenhams is considering closing up to 10 of its 176 stores, with its shops in Lincolnshire potentially at risk.
The department store has announced a “turnaround strategy”, aimed at boosting its appeal as a “destination” shop and improving its online offering.
A total of 11 warehouses could also be closed, including one major distribution centre which employs 220 people.
Debenhams has two stores in the Greater Lincolnshire region – one of St Mark Street in Lincoln and the other on Doncaster Road in Scunthorpe.
Details of the plans emerged as the company recorded a 6.4% drop in pre-tax profits to £87.8 million for the six months to March 4.
Chief executive Sergio Bucher said: “Our customers are changing the way they shop and we are changing too.
“Shopping with Debenhams should be effortless, reliable and fun, whichever channel our customers use.
“We will be a destination for ‘social shopping’ with mobile the unifying platform for interacting with our customers.”